Over at CDL Lost247365 answers a question about the safety of puberty blockers in the treatment of transgender kids, and provides some really useful references to relevant science papers.
She writes:
Puberty blockers have almost universally been shown to result in positive outcomes and to be safe.
QUOTE: “Studies reviewed had samples ranging from 1 to 192 (N = 543). The majority (71%) of participants in these studies required a diagnosis of gender dysphoria to qualify for puberty suppression and were administered medication during Tanner stages 2 through 4. Positive outcomes were decreased suicidality in adulthood, improved affect and psychological functioning, and improved social life. Adverse factors associated with use were changes in body composition, slow growth, decreased height velocity, decreased bone turnover, cost of drugs, and lack of insurance coverage. One study met all quality criteria and was judged ‘excellent’, five studies met the majority of quality criteria resulting in 'good’ ratings, whereas three studies were judged fair and had serious risks of bias.”
https://www.aap.org/en/news-room/news-r … -blockers/
QUOTE: “Researchers found a 60% decrease in moderate and severe depression and 73% decrease in suicidality among transgender and non-binary youth who received puberty blockers or gender-affirming hormones over a 12-month period, according to a study abstract presented during the virtual American Academy of Pediatrics 2021 National Conference & Exhibition.”
https://publications.aap.org/pediatrics … redirected
QUOTE: “This is the first study in which associations between access to pubertal suppression and suicidality are examined. There is a significant inverse association between treatment with pubertal suppression during adolescence and lifetime suicidal ideation among transgender adults who ever wanted this treatment. These results align with past literature, suggesting that pubertal suppression for transgender adolescents who want this treatment is associated with favorable mental health outcomes.”
https://www.thelancet.com/journals/land … cestitle70
QUOTE: Gender incongruence in children and adolescents is complex, and medical treatment raises several ethical considerations. Clinical decision making has been fostered by research efforts, but there are still substantial knowledge gaps that warrant examination to inform best clinical practice (panel 4). The limited available evidence suggests that puberty suppression, when clearly indicated, is reasonably safe. The few studies that have examined the psychological effects of suppressing puberty, as the first stage before possible future commencement of CSH therapy, have shown benefits.
All of this should also show that puberty blockers are not experimental and are life saving:
QUOTE: “Puberty delaying medications are currently provided off label to adolescents affected by gender dysphoria and this particular use cannot be investigated by a RCT. We have shown that this does not mean they are experimental drugs or are provided experimentally. Whether or not these (or even approved drugs) are ethically prescribed depends on whether they are likely to serve the patient’s health interests based on the evidence available at the time of prescription.
"The published literature provides insight into the likely benefits of GnRHa. In summary, they reduce the patient’s dysphoria (Cohen-Kettenis & Pfäfflin, 2003, p. 171; Kreukels & Cohen-Kettenis, 2011, p. 467), reduce the invasiveness of future surgery (for example, mastectomy in trans men; treatment for facial and body hair, thyroid chondroplasty to improve appearance and cricothyroid approximation to raise the pitch of the voice in trans women) (Cohen-Kettenis & Pfäfflin, 2003, p. 171); GnRHa is correlated with improved psychosocial adaptation (Cohen-Kettenis & Pfäfflin, 2003, p. 171; Kreukels & Cohen-Kettenis, 2011, p. 467) and reduced suicidal ideation and attempts. Hembree noted increased suicidal ideation where blockers were not given (Hembree, 2011; see further, Imbimbo et al., 2009; Kreukels & Cohen-Kettenis, 2011; Murad et al., 2010; Spack, 2008).”
Some people think that puberty blockers might cause kids to think they are transgender and convince them to wrongfully go on to take HRT. The research shows this not to be true:
QUOTE: “In this cohort study of TGD adolescents, GnRHa use was not associated with increased subsequent GAH use. These findings suggest that clinicians can offer the benefits of GnRHa treatment without concern for increasing rates of future GAH use.”
Puberty blockers are in fact a wonder drug. Extremely safe and they can prevent trans kids from experiencing irreversible changes to their body due to the wrong puberty while they reach an age where they are old enough to consent. Similarly, they prevent confused Cis Children (who make up only about 2% of all the kids pursuing puberty blockers) from making a mistake that would create irreversible changes to their body as well. Meaning that this drug helps both trans and cis kids!
You can read the whole post here.
